Description
General Description
Hyaluronic acid thiol (HA-SH) is a chemically modified derivative of hyaluronic acid in which thiol (-SH) groups are introduced onto the polymer backbone. These reactive groups enable covalent crosslinking through disulfide bond formation or thiol-reactive chemistries.
Key Properties
- Thiol-functionalized polysaccharide
- Enables disulfide bond formation and crosslinking
- Retains native biocompatibility of hyaluronic acid
- Water-soluble and reactive biomaterial platform
- Suitable for injectable and in situ forming systems
Applications
- Hydrogel formation and crosslinking systems
- Drug delivery and controlled release formulations
- Tissue engineering scaffolds
- Wound healing biomaterials
- Mucoadhesive formulations
- Bioconjugation via thiol-reactive chemistry
Functional Overview
Thiol modification enables redox-responsive and covalent network formation, allowing tunable mechanical properties and degradation behavior in biomaterial design.
Summary
Hyaluronic acid thiol is a versatile functional polymer widely used in hydrogel engineering, drug delivery, and regenerative medicine due to its reactive thiol chemistry and excellent biocompatibility.
