PEI-g-PEG-Maleimide is a graft copolymer of branched PEI (bPEI), which is modified with multiple Maleimide-PEGs of indicated MW. The PEG to PEI ratio is the average number of PEGs per PEI. Custom service is provided to produce PEG-PEI reagents with any MW of PEI and any MW of PEG at any graft ratio PEG-g(x)-PEI, x is the PEG to PEI ratio.
Copolymers of cationic poly(ethyleneimine) grafted with maleimide-polyethylene glycol (PEG) (PEI-g-PEG-Maleimide) are extremely well-studied compounds that markedly improve the in vitro and in vivo delivery of oligonucleotides (AOs) to cells and tissues. By varying the Mw of PEI, as well as the nature of PEG shielding, PEG-PEI-AO nanoparticulates can be prepared with a dynamic range of size, surface charge, and stability. Each of these properties in-turn influences the transfection capacity of the PEG-PEI-AO polyplexes. In addition, PEG-PEI copolymers are readily functionalized for enhanced efficacy and specificity of cellular and tissue targeting.
PEI-g-PEG-Maleimide can be used to prepare cationic nanoparticles for targete gene/AOS delivery. Maleimide can react with thiol-containing groups.