About NSP

Nanosoft Polymers (NSP)  specializes in  bridging the gap betwepolymer1en polymer and drug delivery by supplying ready-to-use funcitonalized polymer & copolymers  for use in therapeutics, devices and diagnostics.

homepage-pic2NSP manufactures and sells a unique collection of functional polymers,  copolymers, and polymer conjugates. NSP's polymer catalog includes functional PLGA-PEG, PLA-PEG, PCL-PEG, lipid-PEGs, poly(L-lysine)-PEG, poly(L-glutamic acid)-PEG and pegylation reagents that can be used in your research involving drug/gene delivery, encapsulation, cell adhesion and surface modification.

NSP also specializes in  polymer synthesis and functionalization, nanoparticle fabrication, surface modificaiton, and custom synthesis of reactive oligomers and polymers with a broad range of molecular weights. 

Our Mission  

We are dedicated to building a long-term, trusting relationship with our customers  by offering quality functional polymers and copolymers backed up with exceptional customer service and technical support. 

High quality We guarantee the superior quality of our products by providing real analytical data  with excellent lot-by-lot reproducibility.

Quick delivery We keep catalog items in stock. Overnight delivery is possible in US. Delivery is quick to other worldwide locations, too.

Simple payment We accept NET 30 days payments, Credit cards, checks, and wire transfers.

Great pricing We provide excellent pricing for our products. Check out our catalog now and compare the prices with our competitors.

Professional support We provide the highest level of technical support to our customers. 

Fast turnaround  Our experienced team work together to make sure quick turnaround for your orders.

New products

Nanosoft Polymers offers multiarm PLGAs for drug delivery  and biomedical research!


Nanosoft Polymers offers Functional linear polyamino acids for drug delivery and surface modification!

Nanosoft Polymers offers functionalized PEI-PEGs for in vitro and in vivo gene delivery!


Nanosoft Polymers offers Functional linear polyamino acids for drug delivery and surface modification!

Nanosoft Polymers offers Folate-PEG-PLA/PLGAfor targeted nanoparticles!

 

Nanosoft Polymers offers DSPE-PEG-DBCO for copper-free click chemistry!

Nanosoft Polymers offers DSPE-PEG-Azide for bioconjugation by "click chemistry"!

Nanosoft Polymers offers PLGA-PEG-Maleimide, and PLGA-PEG-Amine for gene/drug delivery! 

Nanosoft Polymers offers Azide-PEG-PLL and Azide-PEG-pAsp for gene/drug delivery!

Nanosoft Polymers offers custom synthesis for your special demand. Please contact us!

NSP Products In Literature

NSP’s PEGylated polylysine contributed to paper in Nature Communications

Mammalian cells don’t have exterior cell walls for protection, and environmental assaults can easily damage or destroy mammalian cells. Thus, the ability to develop a biomimetic cell wall (BCW) on their plasma membrane as a shield can advance various applications. A recent study published in Nature Communications has synthesized BCW with a framing template and a crosslinked matrix for shielding live mammalian cells. The framing template is a supramolecular DNA structure. The crosslinked matrix is a polyelectrolyte complex made of alginate and Pegylated-polylysine (PLL-MPEG, Nanosoft Polymers). As the entire procedure of BCW synthesis is strictly operated under physiological conditions, BCW-covered mammalian cells can maintain high bioactivity. More importantly, the data show that BCW can shield live mammalian cells from not only physical assaults but also biological assaults. Thus, this study has successfully demonstrated the synthesis of BCW on live mammalian cells with great potential of shielding them from environmental assaults. Nature Communications (2019) 10:2223.

Synergetic ER-targeting Liposome Nanocarriers with Anti-phagocytic property for Enhanced Tumors Theranostics

Multifunctional nanocarriers have been widely applied due to their enhanced effect on tumor therapeutics. Nevertheless, owing to the natural immune clearance mechanisms in living bodies, nanocarriers tend to be eliminated during blood circulation, thereby impeding their effective arrival at the tumor sites. In a recently published paper, the authors constructed a synergetic targeted liposome nanocarrier system named SELS functionalized with both a tumor identification ligand (anti-ER (Estrogen Receptor) antibody) and an immune targeting ligand (Self-Peptide (SP)). DSPE-PEG-Mal (Nanosoft Polymers) was used to conjugate targeting ligand. The anti-ER antibody could recognize and bind ER-positive breast cancer tissues in a specific way. SP could activate the CD47-SIRPα immune response, which reduced phagocytosis of the nanoparticles by macrophages. Both the enhanced targeting ability and anti-phagocytosis behavior could improve the tumor uptake of the nanocarriers and prevent their immune clearance in living systems. Therefore, drug-loaded SELS enabled improved tumor imaging and therapeutic performance in living systems.  Journal of Materials Chemistry B, 48(7 ) 1056-1063.  2019.