t-Butoxycarbonyl-Amine-PEG-Amine (tBoc-NH-PEG-NH2) is a linear heterobifunctional PEG reagent with Boc protected amine and a free amine. It is a useful crosslinking reagent with a PEG spacer. The free amine typically in the form of TFA or HCl salt can be used to react with carboxyl or NHS ester. The protected amine can be regenerated by mild acidic conditions.
Typical method for Boc deprotection