Description
General Description
DOPE-Maleimide is a reactive phospholipid derivative containing DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, C18:1) and a terminal maleimide functional group. The maleimide functionality reacts selectively with thiol-containing molecules under mild conditions to form stable thioether linkages for nanoparticle surface engineering and bioconjugation applications.
Key Properties
- Maleimide-functionalized phospholipid
- Reactive toward thiol-containing molecules
- DOPE phospholipid anchor (C18:1)
- Unsaturated lipid structure for membrane fusion and fluidity
- Suitable for liposome and nanoparticle functionalization
Applications
- Thiol-mediated bioconjugation
- Liposome surface modification
- Lipid nanoparticle (LNP) engineering
- Antibody and peptide conjugation
- Drug and nucleic acid delivery
- Nanomedicine and biomaterial applications
Functional Overview
The DOPE lipid segment provides membrane fusion capability and enhanced membrane fluidity, while the maleimide functionality enables selective conjugation with thiol-containing biomolecules and nanoparticle surfaces.
Summary
DOPE-Maleimide is a versatile thiol-reactive phospholipid widely used in liposome engineering, nanoparticle functionalization, and advanced nanomedicine applications.
