About NSP

Nanosoft Polymers (NSP)  specializes in  bridging the gap betwepolymer1en polymer and drug delivery by supplying ready-to-use funcitonalized polymer & copolymers  for use in therapeutics, devices and diagnostics.

homepage-pic2NSP manufactures and sells a unique collection of functional polymers,  copolymers, and polymer conjugates. NSP's polymer catalog includes functional PLGA-PEG, PLA-PEG, PCL-PEG, lipid-PEGs, poly(L-lysine)-PEG, poly(L-glutamic acid)-PEG and pegylation reagents that can be used in your research involving drug/gene delivery, encapsulation, cell adhesion and surface modification.

NSP also specializes in  polymer synthesis and functionalization, nanoparticle fabrication, surface modificaiton, and custom synthesis of reactive oligomers and polymers with a broad range of molecular weights. 

Our Mission  

We are dedicated to building a long-term, trusting relationship with our customers  by offering quality functional polymers and copolymers backed up with exceptional customer service and technical support. 

High quality We guarantee the superior quality of our products by providing real analytical data  with excellent lot-by-lot reproducibility.

Quick delivery We keep catalog items in stock. Overnight delivery is possible in US. Delivery is quick to other worldwide locations, too.

Simple payment We accept NET 30 days payments, Credit cards, checks, and wire transfers.

Great pricing We provide excellent pricing for our products. Check out our catalog now and compare the prices with our competitors.

Professional support We provide the highest level of technical support to our customers. 

Fast turnaround  Our experienced team work together to make sure quick turnaround for your orders.

New products

Nanosoft Polymers offers multiarm PLGAs for drug delivery  and biomedical research!


Nanosoft Polymers offers Functional linear polyamino acids for drug delivery and surface modification!

Nanosoft Polymers offers functionalized PEI-PEGs for in vitro and in vivo gene delivery!


Nanosoft Polymers offers Functional linear polyamino acids for drug delivery and surface modification!

Nanosoft Polymers offers Folate-PEG-PLA/PLGAfor targeted nanoparticles!

 

Nanosoft Polymers offers DSPE-PEG-DBCO for copper-free click chemistry!

Nanosoft Polymers offers DSPE-PEG-Azide for bioconjugation by "click chemistry"!

Nanosoft Polymers offers PLGA-PEG-Maleimide, and PLGA-PEG-Amine for gene/drug delivery! 

Nanosoft Polymers offers Azide-PEG-PLL and Azide-PEG-pAsp for gene/drug delivery!

Nanosoft Polymers offers custom synthesis for your special demand. Please contact us!

NSP Products In Literature

NSP’s Pegylated Lipid contributed to paper in Nano Letters

Go to Volume 19, Issue 2

Ultrathin Tellurium Oxide/Ammonium Tungsten Bronze Nanoribbon for Multimodality Imaging and Second Near-Infrared Region Photothermal Therapy

Developing nanophotothermal agents (PTAs) with satisfied photothermal conversion efficiency (PTCE) in the second NIR window (1000–1350 nm, NIR II) holds great promise for enhanced photothermal therapy effect. Herein, we develop a NIR-II PTA with advanced PTCE, based on a new two-dimensional ultrathin tellurium oxide/ammonium tungsten bronze (TeO2/(NH4)xWO3) nanoribbons (TONW NRs). The doped ammonia ions-mediated-free-electrons injection into the lowest unoccupied molecular orbital band of WO3 combined with the electronic transitions between W6+ ions and the lone pair of electrons in Te atoms achieve excellent NIR absorption of TONW NRs resulting from localized surface plasmon resonance. The polyethylene glycol functionalized TONW NRs (PEG-TONW NRs) exhibit good stability and biocompatibility, displaying a PTCE high to 43.6%, surpassing many previous nano-PTAs active in the NIR II region, leading to remarkable tumor ablation ability both in vitro and in vivo. Meanwhile, advanced X-ray computed tomography (CT) and photoacoustic (PA) imaging capability of PEG-TONW NRs were also realized. Given the admirable photothermal effect in NIR II region, good biocompatibility, and advanced CT/PA imaging diagnosis capability, the novel PEG-TONW NRs is promising in future personalized medicine applications. Nano Lett.2019, 19, 2, 1179-1189.

NSP’s product contributed to Nature Materials

Hyaluronic acid–bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis

While conventional approaches for inflammatory bowel diseases mainly focus on suppressing hyperactive immune responses, it remains unclear how to address disrupted intestinal barriers, dysbiosis of the gut commensal microbiota and dysregulated mucosal immune responses in inflammatory bowel diseases. Moreover, immunosuppressive agents can cause off-target systemic side effects and complications. Recently, a paper published in Nature Biomaterials,  reported the development of hyaluronic acid–bilirubin nanomedicine (HABN) that accumulates in inflamed colonic epithelium and restores the epithelium barriers in a murine model of acute colitis. Surprisingly, HABN also modulates the gut microbiota, increasing the overall richness and diversity and markedly augmenting the abundance of Akkermansia muciniphila and Clostridium XIVα, which are microorganisms with crucial roles in gut homeostasis. Importantly, HABN associated with pro-inflammatory macrophages, regulated innate immune responses and exerted potent therapeutic efficacy against colitis. The work sheds light on the impact of nanotherapeutics on gut homeostasis, microbiome and innate immune responses for the treatment of inflammatory diseases.  Nanosoft Polymers’ Cholesterol-PEG-NH2  was used to conjugate hyaluronic acid for HABN.   2019 Aug 19. doi: 10.1038/s41563-019-0462-9.