Welcome to NSP
Nanosoft Biotechnology LLC (Nanosoft Polymers, NSP) is launched to bridge the gap between polymer and drug delivery by supplying ready-to-use funcitonalized polymer & copolymers. We manufacture and sell a unique collection of functional polymers, copolymers, and polymer conjugates.
NSP's polymer catalog includes functional PLGA-PEG, PLA-PEG, PCL-PEG, lipid-PEGs, poly(L-lysine)-PEG, poly(L-glutamic acid)-PEG and pegylation reagents that can be used in your research involving drug delivery and surface modification.
We are committed to exceeding our customers' expectations, whether it is in providing the highest quality and reliable polymer materials, or in our unique services such as consultancy and developing new technologies.
We are dedicated to building a long-term, trusting relationship with our customers by offering quality functional polymers and copolymers backed up with exceptional customer service and technical support.
If you have previously worked with functional polymers, give NSP a chance to show you how we can help. If you are currently looking for functional polymers to design your drug delivery, give us a call and we will help you get started.
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Intravital multiphoton microscopy of the kidney is a powerful technique to study alterations in tissue morphology and function simultaneously in the living animal and represents a dynamic and developing research tool in the field. Recent technological advances include serial intravital multiphoton microscopy of the same kidney regions over several weeks and combined with ex vivo histology for cellular biomarker expression of the same cells, which had been subject to serial imaging before. Thus, serial intravital multiphoton microscopy followed by ex vivo histology provides unique tools to perform long-term cell fate tracing of the same renal cells during physiological and pathophysiological conditions, thereby allowing the detection of structural changes of the same renal cells over time. Examples include renal cell migration and proliferation while linking these events to local functional alterations and eventually to the expression of distinct cellular biomarkers. Recently a protocol for long-term cell fate tracking of individual renal cells was published using serial intravital microscopy. The authors provided a detailed step-by-step protocol to facilitate serial intravital multiphoton microscopy for long-term in vivo tracking of renal cells and subsequent ex vivo histology for immunohistological staining of the same cells in the fixed tissue. Schiessl I.M., Fremter K., Burford J.L., Castrop H., Peti-Peterdi J. (2019) Long-Term Cell Fate Tracking of Individual Renal Cells Using Serial Intravital Microscopy. In: . Methods in Molecular Biology. Humana Press. https://doi-org.go.libproxy.wakehealth.edu/10.1007/7651_2019_232.
Porous membranes are ubiquitous in cell co-culture and tissue-on-a-chip studies. These materials are predominantly chosen for their semi-permeable and size exclusion properties to restrict or permit transmigration and cell-cell communication. In a recent study, researchers fabricated micropatterned non-fouling polyethylene glycol (PEG) islands (based on PLL-g-PEI, Nanosoft Polymers) to mimic pores in order to decouple the effect of surface discontinuity from grip provided by pore wall edges. Similar to porous membranes, they found that the PEG islands hindered fibronectin fibrillogenesis with cells on patterned substrates producing shorter fibrils. Additionally, cell migration speed over micropatterned PEG islands was greater than unpatterned controls, suggesting that disruption of cell-substrate interactions by PEG islands promoted a more dynamic and migratory behavior, similarly to cells
migrating on microporous membranes. Preferred cellular directionality during migration was nearly identical between substrates with identically patterned PEG islands and micropores, further confirming disruption of cell-substrate interactions as a common mechanism behind the cellular responses on these substrates. Interestingly, cell spreading and the magnitude of migration speed was significantly greater on porous membranes compared to PEG islands with identical feature size and spacing, suggesting pore edges enhanced cellular grip. These results provide a more complete picture on how porous membranes affect cells which are grown on them in an increasing number of cellular barrier and co-culture studies. https://www.biorxiv.org/content/early/2019/02/28/563361.full.pdf.
Nanomedicine holds great potential for drug delivery to achieve more effective and safer cancer treatment. Recently, one research group in Japan developed a folate receptor-targeting nanocomplex which carries alcoholic extract of Withania somnifera leaves (i-Extract) that has selective cancer cell killing activity, suspends well in water and possesses enhanced selective anticancer activity in both in vitro and in vivo assays. Comparative analyses of folate receptor (FR)-positive and -negative cells revealed that FRi-ExNC caused a stronger decrease in Cyclin D/Cdk4 and anti-apoptotic protein Bcl-2, as well as a higher increase in the growth arrest regulating protein p21WAF1 and pro-apoptotic protein PARP-1, in FR-enriched cancer cells. The results demonstrate that FRi-ExNC could be a natural source-based nanomedicine for targeted cancer therapy. NSP’s DSPE-PEG-Folate was used to construct the nanocomplex for folate receptor-targeting. Front. Oncol., 04 July 2019 | https://doi.org/10.3389/fonc.2019.00602.
Recently, An patent (US20180369231A1) published by SNBioScience Inc. has invented a drug delivery system having a double core-shell structure and, specifically, to a double nano-drug delivery system having an inner core-shell containing a poorly soluble camptothecin compound and a water-soluble camptothecin compound inside and an amphiphilic polymer shell, and to a manufacturing method therefor. The double core-shell structured particles manufactured by the present invention form very stable particles and show a mono-distribution of particles before and after freeze-drying. The particles of the present invention show excellent results compared with existing monolayer micelles in animal efficacy tests and pharmacokinetic tests, and do not use a surfactant causing hypersensitivity, and thus the use of the particles of the present invention can provide a pharmaceutical composition or a drug delivery system platform, which are safe for the human body. NSP’s polymers were used in the formulation. (https://patents.google.com/patent/US20180369231A1/en).