Description
General Description
PLGA-SH combines the biodegradability and biocompatibility of poly(lactic-co-glycolic acid) (PLGA) with a reactive thiol functional group. PLGA has been extensively utilized in controlled drug delivery systems, biodegradable nanoparticles, microspheres, and implantable medical devices.
The terminal thiol group readily reacts with maleimides, vinyl sulfones, acrylates, gold surfaces, and other thiol-reactive compounds, enabling efficient conjugation of peptides, proteins, antibodies, targeting ligands, fluorophores, and other biomolecules. PLGA-SH is commonly employed in targeted nanoparticle development, hydrogel fabrication, surface engineering, and advanced biomaterials research.
Applications
- Nanoparticle fabrication
- Targeted drug delivery
- Thiol-maleimide conjugation
- Antibody conjugation
- Peptide conjugation
- Protein conjugation
- Hydrogel formation
- Surface modification
- Gold nanoparticle functionalization
- Nanomedicine research
Features and Benefits
- Biodegradable and biocompatible PLGA
- Reactive thiol functionality
- Versatile conjugation chemistry
- Suitable for targeted nanoparticle development
- Compatible with maleimide-containing molecules
- Enables stable bioconjugate formation
- Controlled degradation properties
- Available in multiple molecular weights and lactide:glycolide ratios
