Thiol capped 8-arm poly(lactide-co-glycolide) (8-arm PLGA-SH, 8-arm PLGA-SH) is a multiarm PLGA derivative with SH groups at each terminal of the eight arms connected to one trehalose core. The reactive free thiol, SH, sulfhydryl, or mercapto groups selectively react with maleimide and transition metal surface including gold, silver, etc. PLGA-SH can be easily air oxidized to form S-S disulfide (disulphide) bonds, which can be reversed with reducing agents. Otherwise noted, multiarm PLGA is composed of d,l-lactide and glycolide (50:50 ratio).
Appearance: Solid powder or chunk, white to off white to slight yellow.
Purity: >90% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 – 4°C for short term (days to weeks) or -20°C for long term (months to years).
Solubility: Soluble in DMSO, dichloromethane, chloroform, acetone, and DMF
Stock Solution Storage: 0 – 4°C for short term (days to weeks), or -20°C for long term (months).