ALC-0159, α-[2-(ditetradecylamino)-2-oxoethyl]-ω-methoxy-poly(oxy-1,2-ethanediyl) is a PEG-lipid conjugate (i.e. PEGylated lipid). Specifically, it is the N,N-dimyristylamide of 2-hydroxyacetic acid, O-pegylated to a PEG (2,000 Da) (corresponding to about 45-46 ethylene oxide units per molecule of N,N-dimyristyl hydroxyacetamide). It is a non-ionic surfactant by its nature. It has been deployed in the Pfizer-BioNTech SARS-CoV-2 mRNA vaccine (0.05 mg per dose) that contains the active ingredient tozinameran.
Formal Name α-[2-(ditetradecylamino)-2-oxoethyl]-ω-methoxy-poly(oxy-1,2-ethanediyl) CAS Number 1849616-42-7 Molecular Formula (C2H4O)nC31H63NO2 Purity ≥95% Solubility DMF: 10 mg/ml DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml DMSO: Slightly Soluble Ethanol: 1 mg/ml