Description
DSPE-PEG-FITC (Fluorescein-Labeled DSPE-PEG)
DSPE-PEG-FITC is an amphiphilic lipid–polyethylene glycol (PEG) conjugate consisting of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE), PEG, and a covalently attached fluorescein (FITC) fluorescent dye.
This PEGylated phospholipid is widely used in the preparation of liposomes, micelles, and lipid-based nanoparticles, serving both structural and imaging functions.
The DSPE lipid anchors into lipid bilayers, while the PEG chain improves colloidal stability, aqueous solubility, and prolonged circulation time. The FITC label provides strong green fluorescence, enabling easy detection and tracking of nanocarriers.
Key Applications
- Preparation of fluorescently labeled liposomes and micelles
- Drug and gene delivery system research
- Cellular uptake and biodistribution studies
- Vaccine delivery and nanocarrier tracking
- Surface labeling for imaging and diagnostic applications
Functional Advantages
- Amphiphilic structure enables self-assembly into lipid nanostructures
- PEGylation enhances stability and in vivo circulation time
- FITC provides bright green fluorescence signal
- Suitable for fluorescence microscopy and spectroscopy detection
- Useful for tracking nanoparticle uptake and distribution
Summary
DSPE-PEG-FITC is a multifunctional fluorescent lipid–PEG conjugate designed for stable nanocarrier formation and real-time imaging of drug delivery and biological processes.
