HO-PLGA-SH, or α-hydroxyl-ω-thiol poly(D,L-lactide-co-glycolide), is a linear heterofunctional polyester with hydroxyl on one end and thiol group on the other.
Thiol capped poly(L-lactide-co-glycolide) (PLGA-thiol, PLGA-SH, thiol terminated PLGA ) can be used to prepare nanoparticles. Thiol, or SH, sulfhydryl, or mercapto group selectively reacts with maleimide, OPSS, vinylsulfone and transition metal surface including gold, silver, etc.
Poly (lactic-co-glycolic acid) (PLGA) is one of the most effective biodegradable polymeric nanoparticles (NPs). It has been approved by the US FDA to use in drug delivery systems due to controlled and sustained- release properties, low toxicity, and biocompatibility with tissue and cells.