Tritylthiol terminated poly-L-lysine (PLL-tritylthiol, Tritylthiol-PLL, Trt-SH-PLL, PLL-Trt-SH) is a positively charged synthetic polyamino acid terminated with trityl protected SH. It is a crystalline solid soluble in water. Applications for poly-L-lysine include the promotion of cell adhesion to solid substrates for culture dishes or slides, the conjugation to active molecules for improved activities, the layer-by-layer deposition techniques, and the complexation with nucleic acids for gene expression.
Tritylthiol Poly-L-lysine can be offered in form of hydrochloride. Trityl group can be easily removed by TFA to obtain free SH.
SH-terminated polymers were used to selectively react with maleimide and transition metal surface including gold, silver, etc.