Description
General Description
PLGA-Maleimide combines the biodegradability and biocompatibility of poly(lactic-co-glycolic acid) (PLGA) with the highly reactive maleimide functional group. PLGA has been extensively used in controlled drug release systems, biodegradable nanoparticles, microspheres, and implantable medical devices.
The terminal maleimide group readily reacts with sulfhydryl-containing molecules under mild conditions, forming stable thioether bonds. This enables efficient conjugation of antibodies, peptides, aptamers, proteins, and other targeting moieties to PLGA nanoparticles, facilitating the development of targeted drug delivery systems and advanced biomaterials.
Applications
- Nanoparticle fabrication
- Targeted drug delivery
- Antibody conjugation
- Peptide conjugation
- Protein conjugation
- Surface modification
- Controlled drug release
- Nanomedicine research
- Biomaterials engineering
- Diagnostic and imaging applications
Features and Benefits
- Biodegradable and biocompatible PLGA
- Reactive maleimide functionality
- Selective thiol conjugation chemistry
- Suitable for targeted nanoparticle development
- Enables stable thioether bond formation
- Compatible with peptides and antibodies
- Controlled degradation properties
- Available in multiple molecular weights and lactide:glycolide ratios
