4-arm PLGA-NH2 structure

4-Arm PLGA-NH₂

Price range: $260.00 through $960.00

4-Arm PLGA-NH₂ (Four-Arm Poly(lactic-co-glycolic acid)-Amine) is a star-shaped biodegradable polymer consisting of four PLGA chains terminated with primary amine (NH₂) groups. Compared with linear PLGA-NH₂, 4-Arm PLGA-NH₂ offers higher functional group density, enhanced conjugation efficiency, improved drug loading capability, and greater control over polymer architecture. The terminal amine groups enable versatile conjugation with activated esters, carboxylic acids, aldehydes, and other reactive molecules, making this polymer ideal for drug delivery, nanoparticle functionalization, hydrogel formation, and biomaterials research.

Product Specifications

Product Name: 4-Arm PLGA-NH₂
Polymer Composition: Four-Arm Poly(lactic-co-glycolic acid)-Amine
Molecular Weight: Custom molecular weights available
Lactide:Glycolide Ratio: 50:50, 65:35, 75:25, 85:15, Custom
Functional Groups: Amine (NH₂)
Appearance: White to off-white solid
Solubility: DMSO, DMF, Acetone, THF, Dichloromethane, Chloroform
Storage: -20°C, dry and protected from light
Purity: Typically ≥95%

4-arm PLGA-NH2 structure

 

SKU: 12987 Categories: , ,

Description

General Description

4-Arm PLGA-NH₂ is a multifunctional biodegradable polyester designed for advanced drug delivery and biomedical applications. The polymer consists of four PLGA chains radiating from a central core, with each arm terminating in a reactive primary amine group.

The amine functionalities provide versatile sites for covalent attachment of peptides, proteins, antibodies, targeting ligands, fluorophores, and other biomolecules. Compared with linear PLGA derivatives, the multi-arm architecture provides significantly higher end-group density, allowing efficient preparation of multifunctional nanoparticles, targeted delivery systems, and crosslinked biomaterials.

Upon hydrolysis, the polymer degrades into lactic acid and glycolic acid, making it suitable for biodegradable pharmaceutical and biomedical applications.

Applications

  • Drug delivery systems
  • Polymeric nanoparticles
  • Injectable biomaterials
  • Controlled drug release
  • Hydrogel formation
  • Tissue engineering
  • Regenerative medicine
  • Surface modification
  • Protein conjugation
  • Nanomedicine research

Features and Benefits

  • Star-shaped PLGA architecture
  • Biodegradable and biocompatible
  • Higher end-group density than linear PLGA
  • Enhanced drug loading capability
  • Tunable degradation properties
  • Suitable for hydrogel and nanoparticle fabrication
  • Available in various lactide:glycolide ratios
  • Functionalization-ready polymer platform

Additional information

Molecular Weight

10K, 20K, 40K
Package Size

1g, 5g

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