Boc protected-amine and azide conjugated PEG-carboxylic acid (Boc-amine Azide-PEG-COOH, Azide Boc-amine-PEG-COOH) is a trifunctional PEG derivative, which has amine and alkyne group sharing one end and -COOH group on the other end.
tBoc-amine can be deprotected by acid (TFA) to free amine, which react with carboxylic acid and its active esters, and isocyanates. It can also react with carbonyl such as ketone and aldehyde.
Azide were used to react azide group “click” chemistry in mild condition, which is very useful for bioconjugation.
COOH can react with amine or OH containing entities.