Description
General Description
DMPE-PEG-N₃ is a phospholipid–poly(ethylene glycol) conjugate containing DMPE (dimyristoyl phosphatidylethanolamine) and a terminal azide group. The lipid moiety enables stable incorporation into lipid bilayers, while the azide functionality supports efficient bioorthogonal click chemistry conjugation.
Key Properties
- Phospholipid–PEG conjugate
- Terminal azide (-N₃) functionality
- Suitable for click chemistry (CuAAC / SPAAC)
- Hydrophilic PEG spacer improves solubility and biocompatibility
- Compatible with liposome and nanoparticle surface engineering
Applications
- Liposome surface functionalization
- Lipid nanoparticle (LNP) modification
- Click chemistry bioconjugation
- Drug delivery system development
- Biomaterial and nanoparticle engineering
- Surface immobilization and targeting applications
Functional Overview
The terminal azide group enables selective conjugation with alkyne-functionalized molecules under mild conditions, while the DMPE lipid anchor supports stable membrane incorporation in lipid-based delivery systems.
Summary
DMPE-PEG-N₃ is a versatile lipid PEG conjugate widely used in click chemistry, liposome engineering, and nanoparticle functionalization applications.
