Description
General Description
DMPE-PEG-NH₂ is a phospholipid–poly(ethylene glycol) conjugate containing DMPE (dimyristoyl phosphatidylethanolamine) and a terminal primary amine group. The lipid moiety enables stable incorporation into lipid bilayers, while PEG improves aqueous solubility and steric stabilization.
Key Properties
- Phospholipid–PEG conjugate
- Terminal primary amine (-NH₂) functionality
- Hydrophilic PEG spacer improves solubility and biocompatibility
- Suitable for liposome and nanoparticle surface engineering
- Reactive amine group for covalent conjugation
Applications
- Liposome surface functionalization
- Lipid nanoparticle (LNP) modification
- Bioconjugation and surface coupling
- Drug delivery system development
- Biomaterial and nanoparticle engineering
- Functional lipid formulation research
Functional Overview
The terminal amine group enables efficient conjugation with activated carboxyl groups such as NHS esters, while the DMPE lipid anchor supports stable membrane incorporation in lipid-based delivery systems.
Summary
DMPE-PEG-NH₂ is a versatile lipid PEG conjugate widely used in liposome engineering, nanoparticle functionalization, and targeted drug delivery research.
