DODAP (18:1)

$200.00$800.00

 

Clear
SKU: 26495 Categories: ,

Product Description

DODAP (1,2-dioleoyl-3-dimethylammonium-propane) is an ionizable cationic lipid with lower cytotoxicity and high transfection efficiency. DODAP is neutral at physiological pH, but acquires a positive charge inside the endosome due to the protonation of free amines when pH is lower than its pKa (<7). The electrostatic interactions between DODAP and naturally occurring anionic lipids in endosomal membranes trigger the release of nucleic acid. These interactions promote membrane lytic non-bilayer structures to enable the intracellular delivery of nucleic acid. A common application is in nanomedicine as an ionizable lipid component of nanocarriers (lipid-polymer hybrid nanoparticles, LPNs), widely used to encapsulate bioactive molecules, including mRNA, siRNA, and plasmid DNA as a treatment for diseases.

Additional information

Package size

100mg, 500mg, 1g

Formula Weight: 648.05
Appearance: colorless to light yellow liquid
Synonyms: 1,2-dioleoyl-3-dimethylammonium-propane
CAS#: 127512-29-2
Hygroscopic:   No
Light Sensitive:  Yes
Molecular Formula: C41H77NO4
Purity:  95%