1,2-Dioleoyl-sn–glycero-3-phosphoethanolamine (DOPE)-polyethylene glycol-azide (DOPE-PEG-azide, DOPE-PEG-N3) is is a linear heterobifunctional PEGylation reagent with an unsaturated DOPE phospholipid and maleimide group.
DOPE-PEG-N3 be used to prepare pegylated liposome using Click Chemistry. Azide reacts readily with alkyne or cycloocytne in aqueous solution with or without copper catalyst. It is a useful self-assembling reagent to prepare grafted or PEGylated liposome or micelle while also providing an amine group for bioconjugation. It is often used in targeted drug delivery with the lipid bilayer to improve drug solubility, the PEG to provide stealth property, extend circulation half-life and reduce non-specific protein binding or cell adhesion, and the amine group to bioconjugate targeting molecules including antibody, aptamer, protein, and peptide.
Appearance: Solid wax or chunk, white to off white. Purity: >90% (or refer to the Certificate of Analysis) Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. Storage Condition: Dry, dark and at 0 – 4°C for short term (days to weeks) or -20°C for long term (months to years). Solubility: Soluble in DMSO, dichloromethane, chloroform, acetone, and DMF Stock Solution Storage: 0 – 4°C for short term (days to weeks), or -20°C for long term (months).