Azide-PEG-Lipoic acid (N3-PEG-LA) is a linear heterobifunctional PEG reagent with an azide and a lipoic acid group on the PEG ends. It is a useful crosslinking reagent with a PEG spacer. Azide can be used for molecule conjugation by click chemistry, and lipoic acid can be used to bind to metallic particle or film surface with its -S-S-bond. Azide-PEG-Lipoic acid may be used to for bioconjugation, drug delivery, PEG hydrogel, crosslinker, and surface functionalization.
Lipoic acid group has high affinity to metallic surfaces and have been widely used for gold nanoparticles and quantum dots surfaces. PEGylated lipoic acid is water soluble and can be used directly in aqueous buffer. High quality azide-PEG-lipoic acid (N3-PEG-LA) with a standard quality specification of >90% Substitution.
Heterobifunctional PEG reagents from NSP are generally employed as crosslinking agents or as spacers between two different chemical entities. The PEG moiety in the heterofunctional PEG derivatives provides water solubility, biocompatibility, and flexibility. Applications are especially geared towards the development of antibody drug conjugates.