PEI-b-mPEG is a block copolymer of linear PEI (LPEI) with linear PEG. The terminal end of PEG is an inert, nonreactive group. PEI is ended with hydroxyl group.
PEI-b-mPEG, copolymers of cationic poly(ethylene imine) (PEI) and polyethylene glycol (PEG) are well-studied compounds that markedly improve the in vitro and in vivo delivery of oligonucleotides and nucleic acids (DNA, siRNA). By varying the MW of PEI and PEG, PEG-PEI drug conjugates, polyplexes or nanoparticles can be prepared with a dynamic range of size, surface charge, and stability, which all are important to the transfection efficiency. PEG-PEI copolymers can be synthesized with customer specified MW.