Description
General Description
PLGA-NH₂ (75:25) is a reactive biodegradable polymer containing poly(lactic-co-glycolic acid) (PLGA) with a 75:25 lactide:glycolide composition and a terminal primary amine group. The amine functionality enables conjugation with activated carboxylic acids, NHS esters, and other amine-reactive molecules for nanoparticle surface engineering, bioconjugation, and biomaterial functionalization applications.
The 75:25 lactide:glycolide ratio provides slower degradation behavior and enhanced hydrophobicity compared with lower lactide-content PLGA materials, making it suitable for sustained drug delivery and controlled release applications.
Key Properties
- Amine-functionalized biodegradable polymer
- 75:25 lactide:glycolide composition
- Reactive terminal primary amine group
- Biodegradable and biocompatible PLGA backbone
- Suitable for nanoparticle and microparticle formulation
- Excellent platform for conjugation and surface modification
Applications
- Bioconjugation and surface modification
- Drug delivery systems
- Polymeric nanoparticles and microparticles
- Sustained release formulations
- Biomolecule conjugation
- Biomaterials and nanomedicine applications
Functional Overview
The biodegradable PLGA backbone enables controlled degradation and sustained drug delivery performance, while the terminal amine group enables selective conjugation with activated esters and carboxyl-containing molecules.
Summary
PLGA-NH₂ (75:25) is a versatile amine-reactive biodegradable polymer widely used in nanoparticle engineering, sustained drug delivery, and advanced biomaterial applications.
