About NSP

Nanosoft Polymers (NSP)  specializes in  bridging the gap betwepolymer1en polymer and drug delivery by supplying ready-to-use funcitonalized polymer & copolymers  for use in therapeutics, devices and diagnostics.

homepage-pic2NSP manufactures and sells a unique collection of functional polymers,  copolymers, and polymer conjugates. NSP's polymer catalog includes functional PLGA-PEG, PLA-PEG, PCL-PEG, lipid-PEGs, poly(L-lysine)-PEG, poly(L-glutamic acid)-PEG and pegylation reagents that can be used in your research involving drug/gene delivery, encapsulation, cell adhesion and surface modification.

NSP also specializes in  polymer synthesis and functionalization, nanoparticle fabrication, surface modificaiton, and custom synthesis of reactive oligomers and polymers with a broad range of molecular weights. 

Our Mission  

We are dedicated to building a long-term, trusting relationship with our customers  by offering quality functional polymers and copolymers backed up with exceptional customer service and technical support. 

High quality We guarantee the superior quality of our products by providing real analytical data  with excellent lot-by-lot reproducibility.

Quick delivery We keep catalog items in stock. Overnight delivery is possible in US. Delivery is quick to other worldwide locations, too.

Simple payment We accept NET 30 days payments, Credit cards, checks, and wire transfers.

Great pricing We provide excellent pricing for our products. Check out our catalog now and compare the prices with our competitors.

Professional support We provide the highest level of technical support to our customers. 

Fast turnaround  Our experienced team work together to make sure quick turnaround for your orders.

New products

Nanosoft Polymers offers multiarm PLGAs for drug delivery  and biomedical research!


Nanosoft Polymers offers Functional linear polyamino acids for drug delivery and surface modification!

Nanosoft Polymers offers functionalized PEI-PEGs for in vitro and in vivo gene delivery!


Nanosoft Polymers offers Functional linear polyamino acids for drug delivery and surface modification!

Nanosoft Polymers offers Folate-PEG-PLA/PLGAfor targeted nanoparticles!

 

Nanosoft Polymers offers DSPE-PEG-DBCO for copper-free click chemistry!

Nanosoft Polymers offers DSPE-PEG-Azide for bioconjugation by "click chemistry"!

Nanosoft Polymers offers PLGA-PEG-Maleimide, and PLGA-PEG-Amine for gene/drug delivery! 

Nanosoft Polymers offers Azide-PEG-PLL and Azide-PEG-pAsp for gene/drug delivery!

Nanosoft Polymers offers custom synthesis for your special demand. Please contact us!

NSP Products In Literature

NSP’s DSPE-PEG-Mal were used to develop MMP-2-Controlled Transforming Micelles for Heterogeneic Targeting and Programmable Cancer Therapy

Nanoparticle (NP)-based tumor theranostics have ushered in new opportunities for personalized nanomedicine due to their rational design and functionalization. Through the active-peptide-functionalization,  a research group developed a nanoscale micelles system (named HEKM) which consists of tumor microenvironment-regulated shape-changing with specific recognition abilities for enhanced cellular targeting, internalization and therapy of heterogeneic tumors. As a result, HEKMs could recognize and bind the tumor heterogeneity marker EGFR-HER2 complex, which led to an enhanced tumor targeting effect. In particular, HEKMs could self-assemble into nanorods under normal physiological conditions while transform into nanospheres in the tumor extracellular microenvironment by a sensitive response to matrix metalloproteinase-2 (MMP-2). The nanorods could prolong the blood circulation time while the nanospheres could accelerate tissue penetration in tumors. In vivo dual-modal targeted imaging was realized by FRET-fluorophore conjugation and gadolinium loading in HEKMs. Tumor cell apoptosis was achieved by proapoptotic element integration. The in vitro and in vivo studies both demonstrated that these rationally designed, shape-changing and targeting micelles could achieve maximized drug efficacy and minimum side effects. Theranostics 2019; 9(6): 1728-1740. doi: 10.7150/thno.30915.

NSP’s Lipid were used to develop Endotoxin-adsorbing macrophage-mimetic hybrid liposome for sepsis treatment

Sepsis is a life-threatening condition resulting from bacterial or fungal infections. Common treatments for sepsis, such as antibiotic therapy, are far from satisfactory. Because endotoxin (LPS) is a major pathogenic factor in sepsis caused by gram-negative bacterial infections, neutralization of LPS is a promising therapeutic target. To effectively eliminate LPS, in a recent study published in  Chemical Engineering Journal, a macrophage-mimetic hybrid liposome (M-Lipo) was developed by fusing a macrophage membrane (M-membrane) with artificial lipids (Nanosoft Polymers). The M-membrane could provide an intrinsic binding site for LPS. The artificial PEGylated lipid could stabilize the natural membrane and prolong the circulation of M-Lipo in the bloodstream. These two membranes could complement one another and extend their biofunction as they were integrated. The results showed that M-Lipo had surface proteins similar to those of macrophages and could substantially adsorb LPS. With the help of the PEGylated lipids (Nanosoft Polymers), M-Lipo presented much better stability than the bare M-membrane vesicle. In addition, the pharmacokinetic results revealed that M-Lipo clearly had longer retention (∼16%) in blood (at 12 h) than the natural M-membrane (∼3.3%). By combining these properties, the hybrid M-Lipo not only reduced the toxicity of LPS in vitro but also protected the mouse against endotoxic shock in vivo. In conclusion, the hybrid liposome M-Lipo has the advantages of both natural membranes and artificial materials, eventually leading to the successful treatment of sepsis. Chemical Engineering Journal (31), 15-25, 2019.