Description
General Description
DMPE-PEG-N₃ is a phospholipid–poly(ethylene glycol) conjugate containing DMPE (1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine, C14:0), a hydrophilic PEG spacer, and a terminal azide functional group. The azide group enables bioorthogonal click chemistry conjugation with alkyne-containing molecules.
Key Properties
- Azide-functionalized lipid PEG conjugate
- Suitable for click chemistry reactions (CuAAC / SPAAC)
- DMPE lipid anchor for membrane incorporation
- PEG spacer improves aqueous solubility and steric stabilization
- Biocompatible lipid–polymer hybrid material
Applications
- Liposome and lipid nanoparticle functionalization
- Click chemistry bioconjugation
- Surface modification of nanoparticles and biomaterials
- Targeted drug delivery system development
- Hydrogel and polymer conjugation
- Diagnostic and imaging applications
Functional Overview
The DMPE lipid segment anchors into lipid bilayers, while PEG provides flexibility and stealth properties. The terminal azide group enables selective conjugation with alkyne-functionalized molecules through click chemistry reactions.
Summary
DMPE-PEG-N₃ is a versatile click-functional lipid PEG conjugate widely used in liposome engineering, bioconjugation, and advanced drug delivery applications.
