Description
General Description
DOPE-N₃ is a reactive phospholipid derivative containing DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, C18:1) and a terminal azide functional group. The azide functionality enables highly selective click chemistry reactions with alkyne-containing molecules for nanoparticle surface engineering and bioconjugation applications.
Key Properties
- Azide-functionalized phospholipid
- Suitable for copper-catalyzed and copper-free click chemistry
- DOPE phospholipid anchor (C18:1)
- Unsaturated lipid structure for membrane fusion and fluidity
- Suitable for liposome and nanoparticle functionalization
Applications
- Click chemistry conjugation
- Liposome surface modification
- Lipid nanoparticle (LNP) engineering
- Biomolecule and nanoparticle functionalization
- Drug and nucleic acid delivery
- Nanomedicine and drug delivery applications
Functional Overview
The DOPE lipid segment provides membrane fusion capability and enhanced membrane fluidity, while the terminal azide group enables selective conjugation with alkyne-containing molecules through click chemistry reactions.
Summary
DOPE-N₃ is a versatile click-reactive phospholipid widely used in liposome engineering, nanoparticle functionalization, and advanced nanomedicine applications.
