Description
General Description
Fmoc-NH-PEG-NH₂ is a versatile PEG linker designed for applications requiring orthogonal protection strategies and stepwise functionalization. The terminal free amine readily reacts with activated esters, carboxylic acids, aldehydes, isocyanates, and other amine-reactive molecules, while the Fmoc-protected amine remains temporarily masked during synthesis.
Following selective Fmoc deprotection, the second amine becomes available for further modification, making this reagent highly valuable for peptide synthesis, PEGylation, linker development, targeted drug delivery systems, and multifunctional biomolecule conjugates.
Applications
- Peptide synthesis
- Solid-phase peptide synthesis (SPPS)
- Bioconjugation
- PEGylation
- Drug delivery systems
- Linker synthesis
- Antibody conjugation
- Surface modification
- Biomaterials engineering
- Nanomedicine research
Features and Benefits
- Orthogonally protected amine functionality
- Free primary amine for immediate conjugation
- Fmoc group removable under mild conditions
- Hydrophilic PEG spacer improves solubility
- Reduces steric hindrance during conjugation
- Enables sequential functionalization
- Available in multiple PEG molecular weights
- High purity and reproducible performance
