Description
Maleimide-PEG-NH₂ is a versatile heterobifunctional PEG linker designed for the site-specific conjugation of biomolecules and nanomaterials. The maleimide functionality readily reacts with sulfhydryl-containing peptides, proteins, antibodies, and other biomolecules under mild conditions to form stable thioether linkages.
The terminal primary amine group provides an additional reactive handle for coupling with NHS esters, activated carboxylic acids, aldehydes, isocyanates, and other amine-reactive molecules. The PEG spacer improves water solubility, reduces nonspecific interactions, minimizes immunogenicity, and enhances biocompatibility.
Maleimide-PEG-NH₂ is commonly used in antibody-drug conjugates, nanoparticle surface modification, protein labeling, targeted drug delivery systems, and advanced biomaterials development.
Applications
- Antibody conjugation
- Protein conjugation
- Peptide conjugation
- Nanoparticle surface modification
- Targeted drug delivery
- Antibody-drug conjugates (ADCs)
- Liposome functionalization
- Biomaterials engineering
- Surface immobilization
- Diagnostic applications
Features and Benefits
- Heterobifunctional PEG linker
- Reactive maleimide group for thiol conjugation
- Reactive amine group for versatile coupling chemistry
- Forms stable thioether linkages
- Improves water solubility and biocompatibility
- Reduces nonspecific protein adsorption
- Enables site-specific bioconjugation
- Available in multiple PEG molecular weights
