Amine and Alkyne conjugated PEG-carboxylic acid (Amine alkyne-PEG-COOH, Alkyne amine-PEG-COOH) is a trifunctional PEG derivative, which has amine and alkyne group sharing one end and -COOH group on the other end.
Amine group can react with carboxylic acid and its active esters, and isocyanates. It can also react with carbonyl such as ketone and aldehyde.
Alkyne were used to react azide group “click” chemistry in mild condition, which is very useful for bioconjugation.
COOH can react with amine or OH containing entities.