SKU: 27903 Category:

Product Description

DBCO-Acid (DBCO-COOH) is an amine-reactive non-activated building block used for derivatizing amine-containing molecule in the presence of activators.  In the presence of activators such as EDC or DCC, this reagent can be used to derivatize amine-containing molecules through a stable amide bond.

Dibenzocyclooctyne (ADIBO, DBCO) is one of the most reactive cyclo-alkynes for strain-promoted alkyne azide cycloaddition (SPAAC) – a copper-free click chemistry reaction.

DBCO reacts instantly with azide containing molecules. The reaction rate is much higher than that of copper-catalyzed reaction, and reactions with many other cyclooctynes. Unlike some other cyclooctynes, DBCO does not react with tetrazines – this allows to carry out orthogonal conjugation of azides with DBCO, and trans-cyclooctenes with tetrazines.

This amine-reactive NHS ester provides easy attachment of the reactive moiety to almost any primary or secondary amine group, such as protein, peptide, or small molecule amine.

Additional information


50mg, 100mg, 200mg, 500mg, 1g

CAS No. : 1353016-70-2
Formula : C19H15NO3
M.W :         305.33       
Synonyms :
DBCO acid
Purity  :