1,2-Dimyristoyl-sn-Glycero-3-Phosphoethanolamine-N-[(polyethylene glycol)]-amine

SKU: 28165 Categories: , ,

Product Description

DMPE-PEG-Amine (DMPE-PEG-NH2) is a linear heterobifunctional PEGylation reagent with a DMPE (14:0 PE) phospholipid and a maleimide. It is a useful self-assembling reagent to prepare PEGylated liposome or micelle while also providing a thiol or cysteine reactive maleimide group. It is often used in targeted drug delivery with the lipid bilayer to improve drug solubility, the PEG to provide stealth property, extend circulation half-life and reduce non-specific protein binding or cell adhesion, and the reactive maleimide to bioconjugate targeting molecules including antibody, aptamer, protein, and peptide.

Amine-functionalized lipids can react with carboxylic acid and its active esters, and isocyanates.  Amine can also react with carbonyl such as ketone and aldehyde for  conjugation.

Additional information

Molecular size of PEG

1000, 2000, 3400, 5000

Package size

100 mg, 500 mg, 1g