Description
General Description
DSPE-SH is a reactive phospholipid derivative containing DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine, C18:0) and a terminal thiol (-SH) functional group. The thiol group enables selective conjugation with maleimide-, gold-, and disulfide-reactive systems for advanced bioconjugation and nanomedicine applications.
Key Properties
- Thiol-functionalized phospholipid
- Reactive terminal thiol (-SH) group
- DSPE phospholipid anchor (C18:0)
- Saturated lipid structure for enhanced membrane stability
- Suitable for liposome and nanoparticle functionalization
Applications
- Thiol-mediated bioconjugation
- Liposome surface modification
- Lipid nanoparticle engineering
- Gold nanoparticle functionalization
- Drug and nucleic acid delivery
- Nanomedicine and biomaterial applications
Functional Overview
The DSPE lipid segment provides stable membrane incorporation, while the thiol functionality enables selective conjugation with thiol-reactive molecules, biomaterials, and nanoparticle surfaces.
Summary
DSPE-SH is a versatile thiol-reactive phospholipid widely used in liposome engineering, nanoparticle functionalization, and advanced nanomedicine applications.
