Poly(D,L-lactide)-PEG-Maleimide (PDLLA-PEG-MAL ) is a functional amphiphilic block copolymer to prepare targeted micelles or nanoparticles. Maleimide can conjugate with thiol, SH, sulfhydryl or mercapto group to form a disulfide bond.
Block copolymer micelles are widely used in drug delivery applications. PEG-PLA is a biodegradable polymeric micelle which is used as carriers for hydrophobic drugs like paclitaxel. PEG is the hydrophilic part and PLA is the hydrophobic part which forms the micelle core wherein the hydrophobic drug is loaded.