PEI-g-PEG-N3 is a copolymer of branched poly(ethyleneimine) (PEI) grafted with azide-functionalized PEG for drug/gene delivery.
Copolymers of cationic poly(ethyleneimine) and polyethylene glycol with (PEG) (PEI-PEG) are extremely well-studied compounds that markedly improve the in vitro and in vivo delivery of oligonucleotides (AOs) to cells and tissues. By varying the Mw of PEI, as well as the nature of PEG shielding, PEG-PEI-AO nanoparticulates can be prepared with a dynamic range of size, surface charge, and stability. Each of these properties in-turn influences the transfection capacity of the PEG-PEI-AO polyplexes. In addition, PEG-PEI copolymers are readily functionalized for enhanced efficacy and specificity of cellular and tissue targeting.
Azide group can be used for conjugation alkyne moieties by click chemistry.