- Silane-PEG-DBCO is a linear heterobifunctional PEG reagent with a DBCO and a silane.
- It is a useful crosslinking or bioconjugation reagent with a PEG spacer.
- Silane can be used to react with glass, silica, or other hydroxylated particle surface.
DBCO (dibenzocycolctyne) PEG Silane derivatives can go Click Chemistry reaction without a need of any metal catalysts. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free click reaction, is a bioorthogonal reaction that enables the conjugation of two molecules in aqueous solution. DBCO PEG derivatives possess fast kinetics and stability in aqueous buffer. DBCO reagents can be used to label azide-modified biomolecules spontaneous without the need for toxic Cu catalysts. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.