PDLLA-PEG-NH2 structure

PDLLA-PEG-NH₂

Price range: $300.00 through $1,200.00

PDLLA-PEG-NH₂ (Poly(D,L-lactide)-b-Polyethylene Glycol-Amine) is a tin-free, biodegradable amphiphilic block copolymer consisting of poly(D,L-lactide) (PDLLA) and polyethylene glycol (PEG) terminated with a primary amine group. The hydrophobic PDLLA segment enables drug encapsulation and nanoparticle formation, while the hydrophilic PEG segment improves aqueous solubility and biocompatibility. The terminal amine group provides a reactive site for conjugation with targeting ligands, peptides, antibodies, and other biomolecules. PDLLA-PEG-NH₂ is widely used in polymeric micelles, nanoparticle fabrication, drug delivery, and biomaterials research.

Product Specifications

Product Name: PDLLA-PEG-NH₂
Polymer Composition: Poly(D,L-lactide)-b-Poly(ethylene Glycol)-Amine
Molecular Weight: Custom PDLLA and PEG molecular weights available
Functional Groups: Amine (NH₂)
Appearance: White to off-white solid
Solubility: Water, DMSO, DMF, THF, Chloroform
Storage: -20°C, dry and protected from light
Purity: Typically ≥95%

PDLLA-PEG-NH2 structure

SKU: 24173 Categories: , ,

Description

General Description

PDLLA-PEG-NH₂ is an amphiphilic diblock copolymer widely used in drug delivery, nanoparticle fabrication, and biomaterials research. In aqueous environments, the copolymer can self-assemble into polymeric micelles and nanoparticles with a hydrophobic PDLLA core and a hydrophilic PEG corona.

The terminal amine group enables further functionalization through reactions with activated esters, carboxylic acids, aldehydes, isocyanates, and other amine-reactive molecules. PDLLA-PEG-NH₂ is commonly employed for targeted drug delivery, nanomedicine development, imaging applications, and surface modification.

Applications

  • Polymeric micelle preparation
  • Nanoparticle fabrication
  • Drug delivery systems
  • Targeted drug delivery
  • Gene delivery research
  • Surface modification
  • Biomolecule conjugation
  • Tissue engineering
  • Controlled drug release
  • Nanomedicine applications

Features and Benefits

  • Biodegradable PDLLA block
  • Hydrophilic PEG segment improves biocompatibility
  • Terminal amine group enables versatile conjugation
  • Self-assembles into nanoparticles and micelles
  • Suitable for hydrophobic drug encapsulation
  • Reduces nonspecific protein adsorption
  • Available in multiple molecular weight combinations
  • High purity and reproducible performance

Additional information

PLA Molecular Weight

1000, 2000, 3000, 4000, 5000, 10000
PEG Molecular Weight

1000, 2000, 3000, 5000
Package size

100mg, 1g

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