PDLLA-PEG-N3 structure

PDLLA-PEG-N₃

Price range: $300.00 through $1,200.00

PDLLA-PEG-N₃ (Poly(D,L-lactide)-b-Polyethylene Glycol-Azide) is a tin-free, biodegradable amphiphilic block copolymer consisting of poly(D,L-lactide) (PDLLA) and polyethylene glycol (PEG) terminated with an azide (N₃) group. The hydrophobic PDLLA segment enables drug encapsulation and nanoparticle formation, while the hydrophilic PEG segment improves aqueous solubility and biocompatibility. The terminal azide group provides a versatile handle for copper-catalyzed and copper-free click chemistry conjugation. PDLLA-PEG-N₃ is widely used in polymeric micelles, nanoparticle fabrication, drug delivery, and bioconjugation applications.

Product Specifications

Product Name: PDLLA-PEG-N₃
Polymer Composition: Poly(D,L-lactide)-b-Polyethylene Glycol-Azide
Molecular Weight: Custom PDLLA and PEG molecular weights available
Functional Groups: Azide (N₃)
Appearance: White to off-white solid
Solubility: Water, DMSO, DMF, THF, Chloroform
Storage: -20°C, dry and protected from light
Purity: Typically ≥95%

PDLLA-PEG-N3 structure

SKU: 24123 Categories: , ,

Description

General Description

PDLLA-PEG-N₃ is a tin-free biodegradable block copolymer designed for advanced drug delivery, nanomedicine, and biomaterials research. The amphiphilic structure allows spontaneous self-assembly into polymeric micelles and nanoparticles with a hydrophobic PDLLA core and a hydrophilic PEG shell.

The terminal azide group enables efficient conjugation with alkyne- or DBCO-functionalized molecules through click chemistry, facilitating the attachment of targeting ligands, peptides, proteins, fluorophores, and other bioactive compounds. PDLLA-PEG-N₃ is commonly employed in targeted drug delivery systems, imaging probes, and functional nanoparticle development.

Applications

  • Polymeric micelle preparation
  • Nanoparticle fabrication
  • Drug delivery systems
  • Targeted drug delivery
  • Click chemistry conjugation
  • Surface modification
  • Imaging probe development
  • Gene delivery research
  • Controlled drug release
  • Nanomedicine applications

Features and Benefits

  • Tin-free synthesis process
  • Biodegradable PDLLA block
  • Hydrophilic PEG segment improves biocompatibility
  • Reactive azide group for click chemistry
  • Self-assembles into nanoparticles and micelles
  • Suitable for hydrophobic drug encapsulation
  • Reduces nonspecific protein adsorption
  • Available in multiple molecular weight combinations

Additional information

PLA Molecular Weight

1000, 2000, 3000, 4000, 5000, 10000
PEG Molecular Weight

1000, 2000, 3000, 5000
Package size

100mg, 1g

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