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Product Description

Dibenzocyclooctyne-amine (DBCO-NH2), is a heterobifunctional linker containing a DBCO moiety commonly used for the site-specific functionalization of nanobodies, enabling the addition of reactive DBCO groups for subsequent click chemistry reactions.

Dibenzocyclooctyne (ADIBO, DBCO) is one of the most reactive cyclo-alkynes for strain-promoted alkyne azide cycloaddition (SPAAC) – a copper-free click chemistry reaction.

DBCO reacts instantly with azide containing molecules. The reaction rate is much higher than that of copper-catalyzed reaction, and reactions with many other cyclooctynes. Unlike some other cyclooctynes, DBCO does not react with tetrazines – this allows to carry out orthogonal conjugation of azides with DBCO, and trans-cyclooctenes with tetrazines.


Additional information


50mg, 100mg, 200mg, 500mg, 1g

CAS No. : 1255942-06-3
Formula : C18H16N2O
M.W :         276.33      
Synonyms :
DBCO amine, Dibenzocyclooctyne-amine
Purity  :