DBCO-NHS Ester

Description

General Description

DBCO-NHS ester is a dibenzocyclooctyne (DBCO) functionalized NHS ester reagent designed for copper-free click chemistry and bioconjugation applications. The NHS ester group rapidly reacts with primary amines, while the DBCO moiety enables strain-promoted azide–alkyne cycloaddition (SPAAC) with azide-containing molecules under mild conditions.

Key Properties

• Copper-free click chemistry reagent
• Reactive NHS ester for amine conjugation
• DBCO moiety enables SPAAC reactions
• Rapid and efficient bioconjugation
• Suitable for biomolecule labeling and surface functionalization

Applications

• Copper-free click chemistry bioconjugation
• Protein and antibody labeling
• Surface functionalization of nanoparticles and biomaterials
• Hydrogel and polymer modification
• Drug delivery system development
• Bioorthogonal conjugation applications

Functional Overview

The NHS ester reacts efficiently with amine-containing molecules to form stable amide bonds, while the DBCO group enables selective conjugation with azide-functional compounds without requiring copper catalysis.

Summary

DBCO-NHS is a versatile bioconjugation reagent widely used in copper-free click chemistry, biomolecule labeling, and advanced biomaterial engineering applications.