Description
General Description
DMPE-PEG-amine is a phospholipid–poly(ethylene glycol) conjugate containing DMPE (1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine, C14:0), a hydrophilic PEG spacer, and a terminal primary amine functional group. The amine group enables versatile conjugation with activated carboxylic acids, NHS esters, and other reactive molecules.
Key Properties
- Amine-functionalized lipid PEG conjugate
- Reactive primary amine functionality
- DMPE lipid anchor for membrane incorporation
- PEG spacer improves aqueous solubility and steric stabilization
- Biocompatible lipid–polymer hybrid material
Applications
- Liposome and lipid nanoparticle functionalization
- Amine-reactive bioconjugation
- Surface modification of nanoparticles and biomaterials
- Targeted drug delivery system development
- Hydrogel and polymer conjugation
- Biomolecule and protein modification
Functional Overview
The DMPE lipid segment anchors into lipid bilayers, while PEG provides flexibility and stealth properties. The terminal amine group enables conjugation with activated esters and carboxyl-containing molecules for stable surface functionalization.
Summary
DMPE-PEG-NH₂ is a versatile amine-functional lipid PEG conjugate widely used in liposome engineering, bioconjugation, and advanced drug delivery applications.
