Description
General Description
DSG-PEG-N₃ is a reactive PEGylated lipid conjugate containing distearoyl glyceride (DSG, C18:0), polyethylene glycol (PEG), and a terminal azide functional group. The azide functionality enables highly selective click chemistry reactions with alkyne-containing molecules for nanoparticle surface engineering and bioconjugation applications.
Key Properties
- Azide-functionalized PEGylated lipid
- Suitable for copper-catalyzed and copper-free click chemistry
- Distearoyl glyceride lipid anchor (C18:0)
- Amphiphilic structure for nanoparticle stabilization
- Strong membrane incorporation and stability
- Widely used in LNP and liposome formulations
Applications
- Click chemistry conjugation
- Lipid nanoparticle (LNP) engineering
- Liposome surface modification
- mRNA and siRNA delivery
- Biomolecule and nanoparticle functionalization
- Nanomedicine and drug delivery applications
Functional Overview
The DSG lipid segment enables strong membrane incorporation and enhanced nanoparticle stability, while the PEG chain improves steric stabilization and nanoparticle performance. The terminal azide group enables selective conjugation with alkyne-containing molecules through click chemistry reactions.
Summary
DSG-PEG-N₃ is a versatile click-reactive PEGylated lipid widely used in lipid nanoparticle engineering, nucleic acid delivery, and advanced nanomedicine applications.
