Description
General Description
DSG-PEG-NH₂ is a reactive PEGylated lipid conjugate containing distearoyl glyceride (DSG, C18:0), polyethylene glycol (PEG), and a terminal primary amine group. The amine functionality enables conjugation with activated carboxylic acids, NHS esters, and other amine-reactive molecules for nanoparticle surface engineering and bioconjugation applications.
Key Properties
- Amine-functionalized PEGylated lipid
- Reactive terminal primary amine group
- Distearoyl glyceride lipid anchor (C18:0)
- Amphiphilic structure for nanoparticle stabilization
- Strong membrane incorporation and stability
- Widely used in LNP and liposome formulations
Applications
- Lipid nanoparticle (LNP) engineering
- Liposome surface modification
- Biomolecule conjugation
- Drug and nucleic acid delivery
- Surface functionalization
- Nanomedicine and biomaterial applications
Functional Overview
The DSG lipid segment enables strong membrane incorporation and enhanced nanoparticle stability, while the PEG chain improves steric stabilization and nanoparticle performance. The terminal amine group enables selective conjugation with activated esters and carboxyl-containing molecules.
Summary
DSG-PEG-NH₂ is a versatile amine-reactive PEGylated lipid widely used in lipid nanoparticle engineering, bioconjugation, and advanced nanomedicine applications.
