Description
General Description
HS-PEG-Hydrazide is a versatile bifunctional PEG linker designed for the conjugation of biomolecules and surface functionalization. The terminal thiol group enables attachment to gold nanoparticles, gold-coated surfaces, maleimide-functionalized molecules, and other thiol-reactive materials. The hydrazide group reacts efficiently with aldehyde- and ketone-containing compounds under mild conditions, forming hydrazone bonds.
The hydrophilic PEG spacer improves solubility, flexibility, and biocompatibility while minimizing steric hindrance and nonspecific interactions. HS-PEG-Hydrazide is commonly employed in protein conjugation, antibody modification, nanoparticle functionalization, and targeted drug delivery systems.
Applications
- Protein and antibody conjugation
- Glycoprotein labeling
- Aldehyde-functionalized biomolecule coupling
- Nanoparticle surface modification
- Gold nanoparticle functionalization
- Biosensor fabrication
- Drug delivery systems
- Biomaterials engineering
- Surface PEGylation
- Diagnostic and imaging probe development
Features and Benefits
- Reactive thiol group for versatile conjugation
- Hydrazide group selectively reacts with aldehydes and ketones
- Hydrophilic PEG spacer improves solubility
- Reduces nonspecific adsorption
- Enhances biocompatibility
- Suitable for aqueous bioconjugation reactions
- Available in multiple PEG molecular weight
