PDLLA-PEG-alkyne structure

PLLA-PEG-Alkyne

Price range: $300.00 through $360.00

PLLA-PEG-Alkyne (Poly(L-lactide)-b-Polyethylene Glycol-Alkyne) is a tin-free, biodegradable amphiphilic block copolymer consisting of poly(L-lactide) (PLLA) and polyethylene glycol (PEG) terminated with an alkyne group. The hydrophobic PLLA segment enables drug encapsulation and nanoparticle formation, while the hydrophilic PEG segment improves aqueous solubility and biocompatibility. The terminal alkyne group provides a versatile handle for click chemistry conjugation with azide-containing molecules, making PLLA-PEG-Alkyne ideal for targeted drug delivery, nanoparticle functionalization, and biomaterials research.

Product Specifications

Product Name: PLLA-PEG-Alkyne
Polymer Composition: Poly(L-lactide)-b-Polyethylene Glycol-Alkyne
Molecular Weight: Custom PLLA and PEG molecular weights available
Functional Groups: Alkyne
Appearance: White to off-white solid
Solubility: Water, DMSO, DMF, THF, Chloroform
Storage: -20Ā°C, dry and protected from light
Purity: Typically ā‰„95%

PDLLA-PEG-alkyne structure

SKU: 3289 Categories: , ,

Description

General Description

PLLA-PEG-Alkyne is a tin-free biodegradable block copolymer designed for advanced drug delivery and nanomedicine applications. The amphiphilic structure allows spontaneous self-assembly into polymeric micelles and nanoparticles with a hydrophobic PLLA core and a hydrophilic PEG shell.

The terminal alkyne group enables efficient conjugation through copper-catalyzed azide-alkyne cycloaddition (CuAAC) and related click chemistry reactions. This functionality allows attachment of peptides, proteins, antibodies, fluorophores, targeting ligands, and other biomolecules to create functional nanocarriers and biomaterials.

Applications

  • Polymeric micelle preparation
  • Nanoparticle fabrication
  • Drug delivery systems
  • Targeted drug delivery
  • Click chemistry conjugation
  • Surface modification
  • Imaging probe development
  • Peptide and protein conjugation
  • Controlled drug release
  • Nanomedicine applications

Features and Benefits

  • Tin-free synthesis process
  • Biodegradable PLLA block
  • Hydrophilic PEG segment improves biocompatibility
  • Reactive alkyne group for click chemistry
  • Self-assembles into nanoparticles and micelles
  • Suitable for hydrophobic drug encapsulation
  • Enables efficient conjugation to azide-containing molecules
  • Available in multiple molecular weight combinations

 

Additional information

PLA Molecular Weight

1000, 2000, 3000, 4000, 5000, 10000
PEG Molecular Weight

1000, 2000, 3000, 5000
Package size

100mg

Related products