Description
General Description
DOPE-PEG-N₃ is a phospholipid–poly(ethylene glycol) conjugate containing DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, C18:1), a hydrophilic PEG spacer, and a terminal azide functional group. The azide group enables selective bioorthogonal conjugation through click chemistry reactions with alkyne-containing molecules.
Key Properties
- Azide-functionalized PEG phospholipid
- Suitable for click chemistry reactions (CuAAC / SPAAC)
- DOPE phospholipid anchor (C18:1)
- Unsaturated fusogenic lipid structure
- PEG spacer improves aqueous stability and biocompatibility
Applications
- Liposome and lipid nanoparticle functionalization
- Click chemistry bioconjugation
- Drug and nucleic acid delivery
- Surface modification of nanoparticles and biomaterials
- Targeted nanomedicine applications
- Hydrogel and biomaterial engineering
Functional Overview
The DOPE lipid segment supports membrane fusion and endosomal escape, while the PEG spacer improves steric stabilization and circulation behavior. The terminal azide group enables selective conjugation with alkyne-functionalized molecules through click chemistry reactions.
Summary
DOPE-PEG-N₃ is a versatile click-functional PEGylated phospholipid widely used in liposome engineering, nanomedicine, and advanced drug delivery applications.
