Description
General Description
DOPE-PEG-SH is a phospholipid–poly(ethylene glycol) conjugate containing DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, C18:1), a hydrophilic PEG spacer, and a terminal thiol (-SH) functional group. The thiol group enables selective conjugation with maleimide-, disulfide-, and gold-reactive systems under mild conditions.
Key Properties
- Thiol-functionalized PEG phospholipid
- Reactive terminal thiol (-SH) group
- DOPE phospholipid anchor (C18:1)
- Unsaturated fusogenic lipid structure
- PEG spacer improves aqueous stability and biocompatibility
Applications
- Liposome and lipid nanoparticle functionalization
- Thiol-mediated bioconjugation
- Surface modification of nanoparticles and biomaterials
- Drug and nucleic acid delivery
- Gold nanoparticle functionalization
- Nanomedicine and biomaterial engineering
Functional Overview
The DOPE lipid segment supports membrane fusion and endosomal escape, while the PEG spacer improves steric stabilization and circulation properties. The terminal thiol group enables selective conjugation with thiol-reactive molecules and surfaces.
Summary
DOPE-PEG-SH is a versatile thiol-functional PEGylated phospholipid widely used in liposome engineering, nanomedicine, and advanced bioconjugation applications.
