Description
General Description
DOPE-PEG-Biotin is a phospholipid–poly(ethylene glycol) conjugate containing DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, C18:1), a hydrophilic PEG spacer, and a terminal biotin functional group. The biotin moiety enables high-affinity interaction with streptavidin and avidin systems for targeted delivery and bioconjugation applications.
Key Properties
- Biotin-functionalized PEG phospholipid
- Strong affinity toward streptavidin and avidin
- DOPE phospholipid anchor (C18:1)
- Unsaturated fusogenic lipid structure
- PEG spacer improves aqueous stability and biocompatibility
Applications
- Liposome and lipid nanoparticle functionalization
- Streptavidin-mediated bioconjugation
- Targeted drug and nucleic acid delivery
- Surface modification of nanoparticles and biomaterials
- Biosensor and diagnostic applications
- Nanomedicine and biomaterial engineering
Functional Overview
The DOPE lipid segment supports membrane fusion and endosomal escape, while the PEG spacer improves steric stabilization and circulation properties. The terminal biotin group enables strong and selective interaction with streptavidin-containing systems.
Summary
DOPE-PEG-Biotin is a versatile biotin-functional PEGylated phospholipid widely used in liposome engineering, targeted delivery, and advanced bioconjugation applications.
