Description
General Description
DOPE-PEG-NH₂ is a phospholipid–poly(ethylene glycol) conjugate containing DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, C18:1), a hydrophilic PEG spacer, and a terminal primary amine functional group. The amine group enables versatile conjugation with activated carboxylic acids, NHS esters, and other reactive molecules.
Key Properties
- Amine-functionalized PEG phospholipid
- Reactive primary amine functionality
- DOPE phospholipid anchor (C18:1)
- Unsaturated fusogenic lipid structure
- PEG spacer improves aqueous stability and biocompatibility
Applications
- Liposome and lipid nanoparticle functionalization
- Amine-reactive bioconjugation
- Drug and nucleic acid delivery
- Surface modification of nanoparticles and biomaterials
- Hydrogel and biomaterial engineering
- Targeted nanomedicine applications
Functional Overview
The DOPE lipid segment supports membrane fusion and endosomal escape, while the PEG spacer improves steric stabilization and circulation behavior. The terminal amine group enables conjugation with activated esters and carboxyl-containing molecules.
Summary
DOPE-PEG-NH₂ is a versatile amine-functional PEGylated phospholipid widely used in liposome engineering, nanomedicine, and advanced drug delivery applications.
Summary
DOPE-PEG-MAL is a versatile thiol-reactive PEGylated phospholipid widely used in liposome engineering, nanomedicine, and advanced drug delivery applications.
