PDLLA-PEG-alkyne structure

PDLLA-PEG-Alkyne

Price range: $300.00 through $1,200.00

PDLLA-PEG-Alkyne (Poly(D,L-lactide)-b-Polyethylene Glycol-Alkyne) is a tin-free, biodegradable amphiphilic block copolymer consisting of poly(D,L-lactide) (PDLLA) and polyethylene glycol (PEG) terminated with an alkyne group. The hydrophobic PDLLA segment enables drug encapsulation and nanoparticle formation, while the hydrophilic PEG segment improves aqueous solubility and biocompatibility. The terminal alkyne group provides a versatile handle for click chemistry conjugation with azide-containing molecules, making PDLLA-PEG-Alkyne ideal for targeted drug delivery, nanoparticle functionalization, and biomaterials research.

Product Specifications

Product Name: PDLLA-PEG-Alkyne
Polymer Composition: Poly(D,L-lactide)-b-Polyethylene Glycol-Alkyne
Molecular Weight: Custom PDLLA and PEG molecular weights available
Functional Groups: Alkyne
Appearance: White to off-white solid
Solubility: Water, DMSO, DMF, THF, Chloroform
Storage: -20°C, dry and protected from light
Purity: Typically ≥95%

PDLLA-PEG-alkyne structure

SKU: 23975 Categories: , ,

Description

General Description

PDLLA-PEG-Alkyne is a tin-free biodegradable block copolymer designed for advanced drug delivery and nanomedicine applications. The amphiphilic structure enables self-assembly into polymeric micelles and nanoparticles with a hydrophobic PDLLA core capable of encapsulating hydrophobic drugs and a hydrophilic PEG shell that enhances stability and circulation performance.

The terminal alkyne group participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) and other click chemistry reactions, allowing efficient conjugation of peptides, proteins, antibodies, fluorophores, targeting ligands, and other bioactive molecules. PDLLA-PEG-Alkyne is widely used in the preparation of functional nanocarriers and bioactive materials.

Applications

  • Polymeric micelle preparation
  • Nanoparticle fabrication
  • Drug delivery systems
  • Targeted drug delivery
  • Click chemistry conjugation
  • Surface modification
  • Imaging probe development
  • Peptide and protein conjugation
  • Controlled drug release
  • Nanomedicine applications

Features and Benefits

  • Tin-free synthesis process
  • Biodegradable PDLLA block
  • Hydrophilic PEG segment improves biocompatibility
  • Reactive alkyne group for click chemistry
  • Self-assembles into nanoparticles and micelles
  • Suitable for hydrophobic drug encapsulation
  • Enables efficient conjugation to azide-containing molecules
  • Available in multiple molecular weight combinations

Additional information

PLA Molecular Weight

1000, 2000, 3000, 4000, 5000, 10000
PEG Molecular Weight

1000, 2000, 3000, 5000
Package size

100mg, 1g

Related products